• Alendronate
  • Fosamax
  • Fosamax Plus D
• Risedronate
  • Actonel
  • Actonel W/Calcium
• Etidronate
  • Didronel
• Ibandronate
  • Boniva
• Pamidronate
  • Aredia
• Tiludronate
  • Skelid
• Zoledronic acid
  • Reclast
  • Zometa

Osteoporosis (bone loss) is the primary disease associated with long-term calcium deficiency. Osteoporosis may be associated with bone pain and spinal deformity. Depleted levels of calcium can also cause muscle cramps, irregular heartbeat, and depression.

Although phosphorus deficiency is rare, long-term low levels are associated with muscle weakness, bone pain, mental confusion, loss of appetite, anemia, increased susceptibility to infection, respiratory difficulties, seizures, and even death.

The selected depletions information presented here identifies some of the nutrients that may be depleted by certain medications. The signs and symptoms associated with nutrient deficiency may also indicate conditions other than nutrient deficiency. If you are experiencing any of the signs or symptoms mentioned, it does not necessarily mean that you are nutrient deficient. Nutrient depletion depends upon a number of factors, including your medical history, diet, and lifestyle as well as the length of time you have been taking the medication. Please consult your health care provider; he or she can best assess and address your individual health care needs, and determine if you are at risk for nutrient depletions from these medications as well as others not listed here.

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Cashman KD. Diet, nutrition, and bone health. J Nutr. 2007;137(11):2507S-12S.

Jara A, Lee E, Stauber D, Moatamed F, Felsenfeld AJ, Kleeman CR. Phosphate depletion in the rat: effect of bisphosphonates and the calcemic response to PTH. Kidney Int. 1999;55(4):1434-43.

Ondrak KS, Morgan DW. Physical activity, calcium intake and bone health in children and adolescents. Sports Med. 2007;37(7):587-600.

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