Your health care professional will likely give you specific instructions. Certain supplements are meant to support the digestive process itself, so of course they should be taken at or near mealtime. And fat-soluble vitamins and fish oil supplements are generally recommended with food. In cases where there are no specific advantages for taking the product with or without food, some people find that taking supplements (including herbal supplements) with their meals has the benefits of convenience and a reduced potential for stomach upset.