The initial phase of the Estrium Program (with a targeted eating plan) is generally 8 weeks. Depending on your response, your health care professional may suggest that you continue on the program, continue Estrium or the diet alone, or use some other combination of diet and nutritional supplementation. It may also be advised that you take Estrium only in the second half of your menstrual cycle. For best results, follow your health care professional's guidelines.