Since 2002, the research and development team of our wholly-owned subsidiary, MetaProteomics, LLC, has employed a product development model similar to that used by the pharmaceutical industry—but with a focus on natural ingredients. This model, which we’ve termed the ExpresSyn® Process, combines

• discovery and proof of concept
• formula development
• clinical experience.

This proprietary process allows us to apply cutting-edge scientific methods and nutritional research to the management of chronic illnesses.

A Revolution in Thinking. A Revolution in Science.

The emerging science of nutrigenomics—a term that relates to nutrition and genetics—employs a number of scientific disciplines and technologies, including molecular biology, cell biology, biochemistry, and what we now call systems biology. These technologies and methods have made possible the development of new, safer, and more effective formulas for improved patient outcomes.

The results of MetaProteomics research have led to discoveries of plant-derived molecules that influence physiology in ways that may help address specific chronic health conditions as well as support health at the cellular level. Today, formulas developed through the ExpresSyn Process are helping patients nutritionally manage conditions or symptoms associated with joint health, metabolic syndrome, cardiovascular disease, and postmenopausal bone loss.

Screening Novel Ingredients for Safety & Efficacy

The discovery process begins with screening several hundred molecules (both single molecules and mixtures) derived from foods, spices, and herbs that have a long history of safe use. Once the most active substances have been identified from screening in multiple cell culture lines for a specific therapeutic application, we perform safety studies. In these safety studies, various formulas are evaluated in the appropriate animal model of disease and the lead formula candidates undergo toxicology tests. Formulas with good safety profiles are then evaluated for bioavailability in humans. The final step is to evaluate the best in class formulas for effectiveness and tolerance in controlled clinical studies of patients with the appropriate health conditions.

Building a Portfolio of Proprietary Ingredients

The ExpresSyn Process has been successfully applied in the development of a number of proprietary nutraceuticals and medical foods to nutritionally support specific chronic conditions. As we continue to discover substances with unique health-promoting properties, we add to our source-safe pipeline of natural ingredients that offer a high level of predicted efficacy and safety. Most notably, our portfolio and pipeline includes ingredient combinations that have been shown to effectively modulate the activity of kinases—a mode of action known more commonly in the conventional medical industry.

The Discovery of Natural Selective Kinase Response Modulators

A significant breakthrough in nutrigenomic therapies occurred when our scientific team discovered specific hops (Humulus lupulus) molecules and other plant-derived ingredients that possess selective kinase response modulater (SKRM) characteristics.

Kinases are a family of more than 500 enzymes involved in "intercellular signal transduction", a process by which messages outside a cell are transmitted into the cell, ultimately to the mitochondria and nucleus, where the message for gene expression is translated. Through this process, kinases function to chemically modify the expression of genes that control the production of inflammatory proteins, reactive oxygen species, and other mediators that may negatively impact the body both locally and systemically.

Natural SKRMs are designed to play a therapeutic role by helping to regulate kinase activity to modify gene expression in favor of good health.

SKRMs: Our Discovery Platform for Formula Development

The MetaProteomics research team considers the breakthrough discovery of natural SKRMs as a fundamental contribution to the understanding of how phytochemicals can improve health. Specifically, these significant findings help to demonstrate their role in reducing the risk of chronic health conditions associated with metabolic disturbances and altered kinase signaling. This exciting breakthrough discovery has since become our platform for researching and developing ingredient combinations to address a range of nutritionally-related health conditions.