Table of Contents > Herbs > Hawthorn
Hawthorn
Botanical Name:  Crataegus monogyna/Crataegus laevigata
 
Overview
Plant Description
What's It Made Of?
Available Forms
How to Take It
Precautions
Possible Interactions
Supporting Research

Overview

Hawthorn is commonly used to treat patients with heart failure. It may also be helpful for the treatment of other conditions such as angina, atherosclerosis, hypertension, and some arrhythmias. In addition, the antioxidant bioflavonoids in hawthorn berry protect against injury to blood vessels and may be beneficial in the treatment of certain connective tissue disorders. Further studies are warranted to evaluate the effects of this herb for these specific conditions.


Plant Description

Hawthorn is a common thorny shrub that grows up to five feet tall on hillsides and in sunny wooded areas throughout the world. In May its flowers bloom, but although hawthorn is in the same botanical family as roses, the flowers are not fragrant. They grow in small clusters, and are white, red, or pink. Small berries, called haws, sprout after the flowers. They are usually red when ripe, but they may also be black. Hawthorn leaves are shiny and grow in a variety of shapes and sizes.


What's It Made Of?

Hawthorn medicines start with the leaves, the berries, and sometimes, the flowers (only the white flowers are medicinal). These parts are dried and then made into powder. The powder is put into capsules, or added to alcohol or glycerite (a sweet, non-alcohol liquid), along with water, so you can take it in a liquid form. In liquid forms of botanicals, the alcohol and water create a more digestible form.


Available Forms

Hawthorn comes in capsules, tinctures, standardized fluidextracts, or solid extracts. You can also make a bitter-tasting tea from dried cut hawthorn leaves, flowers, and berries.


How to Take It

Pediatric

There are no known scientific reports to date about the use of hawthorn in children.

Adult

Hawthorn products standardized to contain either 4 to 20 mg flavonoids/30 to 160 mg oligomeric procyanidins, or 1.8% vitexin rhamnoside/10% procyanidins should be used.

Hawthorn for heart failure or angina may require at least six weeks of use, three times per day before an effect is noticed.


Precautions

The American Herbal Products Association (AHPA) gives hawthorn a class 1 safety rating, which indicates that it is a very safe herb with a wide dosage range. Even so, it is always wise to follow recommended dosages. If you are pregnant, do not use hawthorn.

It is extremely important for you to note any changes you feel while you are taking hawthorn. More pain, more angina attacks, more exhaustion while walking or exercising—these are all good reasons to stop taking hawthorn and see your health care provider right away. Even if you don't experience any of these symptoms, see your health care provider if your condition hasn't improved after six weeks of hawthorn treatment. Your progress should be monitored even if you do feel better, so see your health care provider in either case.


Possible Interactions

Although hawthorn reportedly enhances the activity of digoxin, a medication used to treat heart conditions, there are no known reports of interactions between hawthorn and digoxin identified in the literature to date.

In a laboratory study, an alcoholic extract of hawthorn fruit counteracted the effects of phenylephrine, a medication that constricts blood vessels and is commonly found in nasal decongestant products. However, this interaction has not been studied in humans; therefore, the relevance of this interaction to people is unknown at this time.


Supporting Research

Bahorun T, Gressier B, Trotin F, et al. Oxygen species scavenging activity of phenolic extracts from hawthorn fresh plant organs and pharmaceutical preparations. Arzneimittelforschung. 1996;46:1086–1089.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, Mass: Integrative Medicine Communications; 1998.

Blumenthal M, Riggins C. American Botanical Council's Popular Herbs in the U.S. Market. Therapeutic Monographs. Austin Tex: ABC; 1997.

Brinker F. Botanical medicine research summaries. In: Eclectic Dispensary of Botanical Therapeutics. Vol. 2. Sandy, Ore: Eclectic Medical; 1995.

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, Ore: Eclectic Medical; 1998:82-83.

Chaterjee SS. In vitro and in vivo studies on the cardioprotective action of oligomeric procyanidins in a crataegus extract of leaves and blooms. Arzneimittelforschung. 1997;47:821–825.

Chen ZY, Zhang ZS, Kwan KY, et al. Endothelium-dependent relaxation induced by hawthorn extract in rat mesenteric artery. Life Sci. 1993;63(22):1983–1991.

Hahn F, Klinkhammer F, Oberdorf A. Preparation and pharmacological investigation of a new therapeutic agent obtained from Crataegus oxyacantha. Arzneim-Forsch. 1960;10:825–829.

Hobbs C, Foster S. Hawthorn: a literature review. Herbalgram. 1990;22:19–33.

Mashour NH, Lin GI, Frishman WH. Herbal medicine for the treatment of cardiovascular disease. Arch Intern Med. 1998;158:2225–2234.

Mawrey DB. Herbal Tonic Therapies. New Canaan, Conn: Keats; 1993.

Miller L. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158(20):2200–2211.

Semm K. The action of Crataegus alone and in combination with Digitalis purpurea, Digitalis leant, Adonis vernalis, and Convallaria majalis upon the heart of the guinea pig. Arzneim-Forsch. 1952;2:5562–5567.

The Criteria Committee of the New York Heart Association I. Diseases of the Heart and Blood Vessels: Nomenclature and Criteria for Diagnosis. 6th ed. Boston, Mass: Little, Brown; 1964.

Hoffmann D. Hawthorn: The Heart Helper. Alternative & Complementary Therapies. 1995;4:191–192.

Kowalchik C, Hylton W, eds. Rodale's Illustrated Encyclopedia of Herbs. Emmaus, Pa: Rodale Press; 1998.

Leuchtgens H. Crataegus special extract WS 1442 in NYHA II heart failure. A placebo controlled randomized double-blind study [in German]. Fortschr Med. 1993;111:352–354.

Loew D, Albrecht M, Podzuweit H. Efficacy and tolerability of a Hawthorn preparation in patients with heart failure stage I and II according to NYHA—a surveillance study. Presented at the Second International Congress on Phytomedicine; 1996; Munich, Germany.

McGuffin M, Hobbs C, Upton R, Goldberg A. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, Fla: CRC Press; 1997.

Nasa Y, Hashizume AN, Hoque E, Abiko Y. Protective effect of crataegus extract on the cardiac mechanical dysfunction in isolated perfused working rat heart. Arzneimittelforschung. 1993;42II(9):945–949.

Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health Care Professionals. London, England: The Pharmaceutical Press; 1996.

Nikolov N, Wagner H, Chopin J, Della Monica G, Chari VM, Seligmann O. Recent investigations of crataegus flavonoids. Proceedings of the International Bioflavonoid Symposium; 1981; Munich, Germany.

Popping S, Rose H, Ionescu I, Fischer Y, Kammermeier H. Effect of a hawthorn extract on contraction and energy turnover of isolated rat cardiomycocytes. Arzneimittelforschung. 1995;45:1157–1161.

Schmidt U, Kuhn U, Ploch M, Hubner WD. Efficacy of the hawthorn (crataegus) preparation LI 132 in 78 patients with chronic congestive heart failure defined as NYHA functional class II. Phytomedicine. 1994;1:17–34.

Schultz V, Hansel R, Tyler V. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Heidelberg: Springer; 1998.

Schussler M, Holzl J, Fricke U. Myocardial effects of flavonoids from crataegus species. Arzneimittelforschung. 1995;45:842–845.

Tauchert M, Ploch M, Hubner WD. Effectiveness of hawthorn extract LI 132 compared with the ACE inhibitor Captopril: Multicenter double-blind study with 132 NYHA stage II. Muench Med Wochenschr. 1994;136 (suppl):S27–S33.

Trunzler G, Schuler E. Comparative studies on the effects of Crataegus extract, digitoxin, digoxin, and g-strophanthidin in the isolated heart of homeothermals. Arzneim-Forsch. 1962;12:198–202.

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Varga A. Treatment of the coronary syndrome and cardiac failure with Aenylcrat and Adenylcrat-digoxin. Munchen Medizinische Wochenschrift. 1970;112:2247–2251.

Vibes J, Lasserre B, and Gleye J. Effects of a methanolic extract from Crataegus oxycantha blossoms on TXA2 and PGI2 synthesizing activities of cardiac tissue. Med Sci Res. 1993;21:534–436.

Vibes J, Lasserre B, Gleye J, Declume C. Inhibition of thromboxane A2 biosynthesis I vitro by the main components of Crataegus oxyacantha (hawthorn) flower heads. Prostaglandins, Leukotrienes and Essential Fatty Acids. 1994;50:174–175.

Weikl A, Assmus KD, Neukum-Schmidt A, et al. Crataegus special extract WS 1442. Assessment of objective effectiveness in patients with heart failure. Fortschr Med. 1996;114:291–296.

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Wichtl M, ed. Herbal Drugs and Phytopharmaceuticals. Boca Raton, Fla: CRC Press; 1994.

Zapfe G, Assmus KD, Noh HS. Placebo-controlled multicenter study with Crataegus special extract WS 1442: clinical results in the treatment of NYHA II cardiac insufficiency. Presented at the Fifth Congress on Phytotherapy; June 11, 1993; Bonn, Germany.


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Hypertension
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