Why is everyone so obsessed with gut health?
Your gut is where health begins, so it's no wonder everyone is obsessing over gut health lately. Our advanced probiotics are some of the best probiotic supplements available, formulated to support digestion, immune health, and daily vitality—so you feel your best, every day.*
Listen to your gut feeling. It's smarter than you think.
Our Advanced Gut Health Solutions
Scientifically formulated products designed for those seeking the next level of gut health optimization-
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Our most comprehensive formula*
UltraFlora® Complete Probiotic$33.60$42.00
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9-in-1 benefits:
digestion, energy, skin, & more
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84% noticed increased gut
comfort within a week*†
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9 probiotic strains to support overall health*
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For vaginal, urinary & gut health*
UltraFlora® Complete Women's$33.60$42.00
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5-in-1: gut, mind, immune,
vaginal, & urinary support*
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2X the benefits of the
leading women's probiotics*††
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5 targeted probiotic
strains specifically for women*
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For better nutrient absorption*
UltraFlora® Probiotic + Multivitamin$23.80$29.75
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2-in-1 synergistic capsule
with doctor-grade
probiotic*
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100% of your daily value
of key vitamins & minerals*
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1 probiotic strain + 19
nutrients for energy &
vitality*
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Starter probiotic for daily gut support*
UltraFlora® Balance Probiotic$20.40$25.50
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Gentle support for
digestive & immune health*
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Probiotic benefit of 15
kombuchas with no sugar*†††
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Features 2 of the most
clinically studied strains
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Find Your Match in 2 Mins
Have you ever used gut health supplements?Real People. Real Gut Transformations.
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“It's been a game changer for my gut health, digestion, and skin. I've noticed less bloating, clearer skin, and better mental clarity since I started taking it.”
Shop UF Complete Women's
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“I love this product. I take it regularly. It has helped so much with my skin, digestion, mental clarity, bloating, etc. I can't live without it!”
Shop UF Balance
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Why Choose UltraFlora® Probiotics by Metagenics?
You Deserve Gut Support That Doesn't Clock Out
Some gut health supplements pass through your digestive system too fast. UltraFlora® by Metagenics is designed to stick around. Explore how our advanced probiotics provide 24-hour support—and why it matters.*
Read the ScienceRelated Gut Health Articles
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What Your Poop Is Telling You: 5 Questions to Consider
Despite being common, chronic constipation is often overlooked. Yet your stool habits can reveal key insights about gut function, hydration, diet, and overall digestive health—if you know what to look for. Read the article -
Gut Health & Mental Health: Is There a Link?
People with major depressive disorder show much lower gut microbial diversity than those without. A diverse microbiome may help support emotional balance. Read the article -
7 Signs of an Unhealthy Gut & 7 Ways to Improve It
Low gut microbial richness isn't just a gut issue. It's been linked to increased risk of weight gain, insulin resistance, and inflammation—highlighting the gut's powerful influence on whole-body metabolic health. Read the article
Your Gut Health Questions, Answered
Truthfully, it's like comparing an apple to “natural orange flavors.” Most store-bought probiotics can’t compete with the quality, science, and transparency behind Metagenics.
1) Clinical-grade ingredients. We own our supply chain—from responsibly sourced ingredients to in-house manufacturing, and we only use ingredients backed by clinical research.
2) Relentless quality testing. With 70+ quality experts and a $1.5M annual investment, we run nearly 50K tests a year to ensure safety, potency, & purity.
3) Trusted by professionals. Metagenics has been the go-to brand for over 40 years, trusted by 40K+ practitioners. Now, we’re one of the best-kept secrets in supplements.
4) Advanced probiotics that deliver. Our formulas provide 24-hour gut support, start working in 30 minutes, and are made to survive stomach acid so they reach your gut and do their job.
With today’s obsession with gut health, quality matters more than ever. Take the gut health quiz to find your perfect probiotic.
Gut flora, or gut microbiota, refers to the trillions of bacteria living in your digestive system. These microbes help you break down food, absorb nutrients, support your immune system, and even influence your mood. The reason everyone’s obsessed over gut health? When your gut is thriving, the rest of your body often follows. Imbalances, on the other hand, can lead to bloating, fatigue, and even inflammation.
Want to know what your gut might be telling you? Take the quiz to find your gut health match!
CFU stands for “colony forming units.”
It’s the number of live, active bacteria in a probiotic dose—key to knowing if a product can help balance your gut. But CFU alone isn’t enough—the best probiotics survive stomach acid, making sure those bacteria reach your gut alive and ready to do their job.
Of course, getting there is only part of the story. Not all probiotics have the right strains or CFU count to deliver real benefits. That’s one reason why gut health supplements are getting so much attention—people want formulas that actually work.
Not sure which CFU level is right for you? Take the gut health quiz to find your match in 2 minutes.
- Probiotics are the live, good bacteria that support gut balance. - Prebiotics are the food that probiotics eat (like fiber) to grow and thrive. - Postbiotics are the helpful compounds probiotics produce when they break down fiber—like short-chain fatty acids—that supports your body’s naturally ability to calm inflammation.*
Think of them as the dream team your gut needs to stay healthy. This trio is at the center of everyone's obsession with gut health—because together, they support your digestion, immune system, and more.
Curious how it all connects? Read: Why 24-Hour Gut Support Matters in a Probiotic
Yes, probiotics may reduce bloating, gas, and digestive discomfort, especially when those symptoms are caused by imbalances in your gut bacteria or inefficient digestion. Certain strains can support better digestion, but results vary from person to person, and the effectiveness depends on the specific strains used, consistency of use, and the underlying cause of symptoms. That’s part of why gut health is such a hot topic—people are tired of discomfort and looking for real, lasting relief.
Tired of guessing? Start the gut health quiz to find a formula that fits your body.
NOTE: If bloating or gas persists despite probiotic use, it’s important to consult with your healthcare provider to rule out other contributing factors such as food intolerances or gastrointestinal conditions. Probiotics are generally safe for most people, but a tailored approach based on individual needs and symptoms often yields the best results.
The short answer is—it depends.
For short-term issues, like occasional digestive upset, 4–12 weeks may be enough. In these cases, the goal is to rebalance your gut flora in response to a disruption. But many people take probiotics daily to maintain gut health, support immune function, or promote regularity as part of a preventive wellness routine.
Most probiotics are safe for extended use, but it's always a good idea to monitor your response and talk to your doctor—especially if symptoms persist or you’re managing an underlying condition.
Want to build a routine that works? Take the quiz or browse our top gut health supplements.
Some probiotics require refrigeration to maintain their potency, while others are shelf-stable thanks to specialized technology. Always check the label and store as directed. At Metagenics, our line of advanced probiotics is carefully formulated using scientifically validated strains and advanced packaging to ensure stability and potency—guaranteed through the expiration date, even without refrigeration for most formulas.
Ready to find your perfect UltraFlora® match? Start the quiz.
Signs your probiotics are working might include more regular digestion, less bloating, fewer stomach issues, or even improved mood or skin. Effects vary from person to person, but are typically gradual and can take a few days to a few weeks to notice. Because every gut is unique, your results will depend on your own gut health, the specific probiotic strains you're taking, and the symptoms you're trying to manage. Not all probiotics are the same, and not every strain works for every concern. Hence the obsession with finding the right probiotic—it’s personal.
If you don’t see meaningful changes after 4 to 8 weeks of consistent use—or if symptoms get worse—it’s important to talk to your doctor. They can help you figure out if something else might be going on.
Ready to find your perfect fit? Take the gut health quiz or read: 7 Signs of an Unhealthy Gut—and 7 Steps to Improve It.
Usually, yes. But it is generally recommended to take probiotics 1-2 hours apart from medications, especially antibiotics, to avoid potential interactions or reduced effectiveness.
Gut health matters—but so does safety. If you’re immunocompromised or managing a health condition, check with your doctor before starting any probiotic supplement. This ensures the product is appropriate for your specific situation and allows for individualized risk assessment.
Want a science-backed recommendation? Take the gut health quiz.
Metagenics: The Experts in Gut Health
We have been a trusted partner in your health for over 40 years, pioneering probiotic formulation and gut health education. We have scientifically formulated supplements to address gut symptoms and multi-benefit formulas to support whole-body health.
Learn More†Based on May 2024 Metagenics survey of 25 consumers who take UltraFlora Complete.
††Sources: Amazon Stackline Data and product packaging as of May 2025. This chart does not reflect clinical efficacy or head-to-head testing. Individual results may vary.
†††Compared to Health-Ade Kombucha; 1 bottle serving of Pink lady Apple or Pomegranate flavor.