You know the pattern. Bloated by mid afternoon, mentally a step behind, moving through the day at three quarter speed while your digestion follows rules it declines to share. Somewhere between the travel, the takeout, and the deadlines, your gut stopped cooperating. If you have found yourself typing "gut health reset" into a search bar at 10pm, you are asking the right question.
The encouraging part, and I say this as a naturopathic doctor who spends her days on digestion, is that the gut is an unusually forgiving system. Recovery rarely requires deprivation. A real gut health reset is not a penance you serve. It is a deliberate return to the conditions your microbiome needs and has not been getting. What follows is what a reset actually involves, what it decidedly is not, and how to reset your gut health in a way that survives contact with a normal week.
What Is a Gut Reset, Really?
The term has been stretched to cover everything from a sensible week of vegetables to a cayenne lemonade fast, so it is worth defining precisely.
A gut health reset is a concentrated period during which you change the inputs your microbiome receives in order to rebuild a more diverse and stable microbial community. You are not sterilizing anything. You are cultivating. The distinction matters, because learning how to reset gut health has less to do with doing something dramatic to your body than with consistently supplying what it has been missing.
Meet Your Microbiome
It helps to understand what you are feeding before you start feeding it. Trillions of bacteria, yeasts, and other microorganisms populate your digestive tract. Collectively they form your gut microbiome, an ecosystem whose health depends far less on population size than on variety. The most resilient ecosystems are not the most crowded ones. They are the ones where many species occupy distinct niches and cover for each other when conditions shift. Yours behaves the same way, and it falters when a narrow few come to dominate.1
That principle reframes the entire project. A well functioning gut is not a matter of accumulating more bacteria. It is a matter of supporting a broader range of them, because different microbes metabolize different substrates, produce different compounds, and buffer the system when your diet, sleep, or stress load changes. Diversity is what makes a microbiome durable, and restoring it is the actual objective of a reset.
A thriving microbial community earns its keep in several ways:
It produces short chain fatty acids. As your bacteria ferment dietary fiber, they generate compounds called SCFA (short chain fatty acids), which serve as the primary fuel for the cells lining your colon and help maintain the integrity of the gut wall.2 This is the most direct illustration of a broader principle: what you eat determines what your microbiome is capable of producing.
It calibrates your immune system. Roughly seventy percent of immune tissue resides in and around the gut.3 A balanced microbial community helps that system distinguish genuine threats from harmless ones.4
It extends your digestive capacity. Your microbes break down compounds your own enzymes cannot, releasing nutrients that would otherwise pass through untouched.5
It communicates with your brain. Gut and brain maintain a continuous exchange, which is why digestion and mood so often move in step.6
DID YOU KNOW? The lining of your intestine renews itself faster than almost any tissue in the body, with those cells turning over in a matter of days.7 That rapid regeneration explains why many people register a difference within the first week of a gut health reset, even though meaningful shifts in microbial composition take considerably longer.
What a Gut Reset Is Not
This is where good intentions most often go wrong, and where a fair amount of money gets spent on approaches that work against the goal.
It is not a juice cleanse.
Juicing removes fiber, and fiber is the single most important substrate your beneficial bacteria depend on.8 Several days of juice deliver less of precisely what your microbiome needs most.
It is not a colon cleanse.
Flushing the colon is indiscriminate. It clears beneficial organisms along with everything else, and it strips the protective mucus layer lining the gut wall. The likely result is a microbiome further from balance than when you began.9
It is not a detox tea.
Most of these products function as laxatives. The effect is immediate and convincing, but accelerating transit is not the same as rebuilding a microbial community, and habitual use can leave motility more sluggish than it started.10
It is not extreme fasting.
This one warrants nuance, because fasting dominates the conversation around gut resets. A comfortable overnight interval between dinner and breakfast, in the range of twelve hours, aligns with your natural circadian pattern and is a reasonable habit. Prolonged or aggressive fasting is a different proposition.
Your beneficial bacteria depend on the fiber you supply, so extended withdrawal of food starves the very populations you are working to rebuild.11
A reset improves what your microbiome is fed. It does not withhold it.
It is not a supplement standing in for everything else.
Supplements have a legitimate and specific role, covered in detail below. What they cannot do is substitute for the daily inputs underneath them. What does work is unglamorous and well established: feed the beneficial populations, reduce what disrupts them, and give your body the sleep, movement, and regulation required to do the rebuilding.
That is the entire architecture of a real gut health reset, and the rest of this article works through it.
Signs Your Gut Is Asking for a Reset

The body signals dysfunction reliably. The difficulty is that these signals are easy to normalize. Consider a reset if you regularly contend with:
Bloating and gas that accumulate as the day progresses
Persistent low energy, the sense of operating at partial capacity
Unpredictable digestion, whether constipation, loose stools, or an alternating pattern
Cognitive fog, that distinct difficulty holding focus
Frequent cravings, particularly for sugar and refined carbohydrates
Getting sick more often than seems warranted, which may reflect strain on gut based immune function
Reactive skin, given how closely the gut and skin are connected
Mood that tracks with digestion, a reflection of that continuous gut and brain exchange
Patients describe this to me as gut burnout, which is an apt phrase. It is seldom one dramatic symptom. It is an accumulation of small ones that together amount to not feeling like yourself. The useful news is that the habits responsible are largely the same ones capable of reversing it.
WHEN TO CHECK IN WITH A PROVIDER
Certain symptoms fall outside the scope of any lifestyle plan. Blood in the stool, unexplained weight loss, persistent vomiting, fever accompanying digestive symptoms, or pain that wakes you at night all warrant medical assessment, as do symptoms that are severe or simply not improving. These merit a proper clinical evaluation rather than a reset.
What Throws Your Gut Off in the First Place
Understanding what you are recovering from makes the recovery more targeted. What surprises most people is how ordinary the causes are. None of these represent a personal failure. They are features of contemporary life, and they compound.
Insufficient fiber variety. Most adults fall short of recommended fiber intake, and even those who meet it often rotate through a narrow set of plants. Microbial diversity responds to the range of substrates available, not merely the quantity.12
An extended stretch of processed eating. Holidays, deadlines, and difficult seasons happen. Sustained periods low in fiber and high in refined ingredients shift which populations flourish.13
Antibiotics. Necessary and at times lifesaving, but indiscriminate in their effect on beneficial organisms.14
Chronic stress. Ongoing stress alters gut motility, visceral sensitivity, and microbial composition itself.15
Irregular or insufficient sleep. Your microbiome keeps time, and erratic sleep disrupts that rhythm.16
Sedentary stretches. Physical activity correlates with greater microbial diversity, so extended inactivity registers in the gut as well.17
Excess alcohol. It irritates the intestinal lining and shifts microbial balance.18
For a fuller treatment of this, we have a detailed breakdown of the 5 factors that may affect your gut microbiome. The pattern worth noticing is that nearly every item is reversible. That is precisely why a gut health reset works.
How to Reset Your Gut
What follows is the practical framework for how to reset your digestive system without dismantling your life. Seven steps, each grounded in research, none requiring hardship. Perfection across all seven is not the standard. Begin where the friction is lowest and let the results recruit you into the rest.
Step 1: Feed the Good Bacteria
This is the highest yield intervention available to you, which is why it comes first. Your beneficial bacteria run on fiber, and most of us supply far too little.
Three categories of food do the heavy lifting:
Fiber
Build intake across a wide range of plants: vegetables, fruits, legumes, whole grains, nuts, and seeds. Fiber is the raw material from which your bacteria synthesize those short chain fatty acids.2 Researchers often point to a target of roughly thirty distinct plant foods across a week, which sounds demanding until you account for herbs, spices, seeds, and different varieties of the same vegetable.12 The operative variable is range, not precision.
Daily Fiber Boost
Supports bowel motility*
Prebiotics
These are specific fibers that preferentially nourish beneficial populations, concentrated in garlic, onions, leeks, asparagus, oats, and slightly underripe bananas.19 One useful mechanism worth knowing: cooking and then cooling starchy foods such as potatoes, rice, and pasta converts a portion of their starch into resistant starch, a form that escapes digestion in the small intestine and reaches the colon intact, where your bacteria ferment it.20 Yesterday's rice is doing more for you than today's.

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Fermented foods
Yogurt, kefir, sauerkraut, kimchi, and miso deliver live beneficial organisms directly. Research from Stanford found that a diet rich in fermented foods increased microbiome diversity and reduced inflammatory markers, a substantial result from an entirely palatable intervention.21 If you are weighing food based sources against a capsule, we examine probiotic foods versus supplements in depth.
One practical caveat: if your current fiber intake is low, increase it incrementally. Moving from minimal fiber to a large volume overnight reliably produces gas and bloating, which is the opposite of the intended outcome. Add gradually over several days and allow your microbial populations to adapt. Where consistency proves difficult, a daily fiber supplement such as MetaFiber can close the gap while the food habits take hold.
Step 2: Cut the Gut Disruptors
Just as certain foods support beneficial populations, others favor the ones you are trying to keep in check. For the duration of a reset, ease back on:
Added sugar, which encourages the proliferation of less helpful organisms and sustains the craving cycle
Ultra processed foods, typically low in fiber and high in ingredients that offer your microbiome little
Excess alcohol, which irritates the intestinal lining and disrupts microbial balance
Note the phrasing: ease back, not eliminate permanently. This is not an exercise in restriction or anxiety. It is a matter of reducing the load long enough for the system to recover.
Here is a reframe that serves my patients better than any list of prohibitions. Concentrate on what you are adding rather than what you are removing. When meals are built around plants, fiber, and fermented foods, the ultra processed options tend to get displaced without a confrontation. Addition is more sustainable than subtraction, and considerably more pleasant.
Step 3: Hydrate to Keep Things Moving
Simple, and routinely underestimated. Water governs transit through the digestive tract, and it works in tandem with the fiber you have just increased.
The mechanism is worth understanding. Soluble fiber functions by absorbing water and forming a soft gel that moves smoothly through the intestine. Without adequate fluid, that same fiber becomes dense and difficult to pass. This is exactly why increasing fiber without increasing water can produce more constipation rather than less.22 The two are not independent variables.
Drink accordingly. Herbal teas and water dense foods such as cucumber, watermelon, and soups all contribute to the total.
Step 4: Move Daily for a More Diverse Microbiome
The requirement is consistency, not intensity.
Regular physical activity correlates with greater microbial diversity, and several mechanisms appear to be at work.17 Movement stimulates the coordinated muscular contractions that propel contents through the digestive tract, supporting regularity.23 It also appears to favor bacteria that produce those beneficial short chain fatty acids. And because exercise moderates the stress response, it reaches the gut through that channel as well.
A brisk walk, a bike ride, yoga, or a session of moving furniture around the kitchen all qualify. One efficient option: a ten-to-fifteen-minute walk after your largest meal supports digestion and blood sugar simultaneously. The most effective exercise for your gut remains the one you will continue doing in March.
Step 5: Protect Your Sleep and Circadian Rhythm
Your gut bacteria keep a schedule, which tends to surprise people.
Research demonstrates that the microbiome follows a daily rhythm closely coupled to your own sleep and wake cycle, with both the composition and the metabolic activity of gut bacteria shifting measurably across a twenty-four-hour period.16 When sleep becomes erratic, that rhythm decouples, and studies link poor sleep and disrupted circadian timing to a less favorable microbial profile.24,25 Anyone who has worked night shifts or crossed several time zones has observed this directly, usually as digestion that behaves strangely for a few days.
Treat sleep as a component of your gut protocol, because it functions as one:
Hold consistent sleep and wake times, weekends included
Get natural light early in the day to anchor the rhythm
Wind down deliberately and reduce screen exposure before bed
Finish eating a couple of hours before sleep, allowing a comfortable overnight interval
Step 6: Lower Stress, Because Your Gut Brain Axis Is Listening
Gut and brain maintain a bidirectional exchange known as the gut brain axis, carried in large part along the vagus nerve.26 This is why anticipation produces butterflies, and why sustained stress manifests as genuine digestive symptoms. Signals travel in both directions, so the relationship compounds.
The effects are concrete rather than abstract. Stress alters transit speed, which presents as either urgency or constipation. It heightens visceral sensitivity, so ordinary digestive activity registers as discomfort. Over time it shifts microbial composition. None of this is imagined. It is anatomical.
Stress cannot be eliminated, but its physiological impact can be blunted. A few minutes daily of slow breathing, a walk outdoors, writing, or simply stepping away from a screen measurably calms traffic along that axis. Extended exhales are particularly effective, since lengthening the out breath is among the more direct means of shifting your nervous system toward its rest and digest state.27 If this relationship interests you, we go further into the gut and brain patterns that influence energy, mood, and motivation.
This is not an optional refinement. It is structural.
Step 7: Go Easy on Antibiotics and Unnecessary Medications
Antibiotics are essential medicine and sometimes lifesaving. They are also indiscriminate, clearing beneficial populations alongside pathogenic ones, which is why digestion so often deteriorates during a course and why the microbial consequences can persist for months afterward.14
The conclusion is not to avoid or fear necessary medication. Never discontinue a prescribed antibiotic on your own judgment. The conclusion is to reserve them for situations that genuinely require them, take them exactly as prescribed, and support recovery deliberately once the course is complete. It is also worth reviewing your regular medications with your provider, since several common classes influence digestion.
During that rebuilding phase, a targeted probiotic such as UltraFlora Restore or UltraFlora BiomePro can help the microbiome re-establish itself.28
A Simple Gut Reset Plan to Start This Week
Frameworks are useful. Specifics are actionable. Here is how to begin without restructuring your entire life at once.
Your First 3 Days
Deliberately modest:
Build every meal around plants, aiming for as much variety in color and type as you can manage.
Add one fermented food daily. A spoonful of sauerkraut, a small glass of kefir, a serving of yogurt.
Reduce the obvious disruptors. Ease back on added sugar, ultra processed snacks, and alcohol.
Hydrate with intent. Keep water accessible and actually drink it.
Walk daily. Fifteen or twenty minutes is sufficient.
Fix a bedtime. Choose a wake time and hold it, weekend included.
The objective in these three days is not transformation. It is sending your microbiome an unambiguous signal that conditions have changed.
Building It Into a Sustainable Week
Once the first few days feel manageable, layer in what makes this durable. One workable sequence:
Focus | What to do | Why it matters |
Days 1 to 3 | Plants at every meal, one fermented food daily, increased water | Begins supplying substrate to beneficial populations immediately |
Days 4 to 7 | Add a daily walk and consistent sleep and wake times | Supports microbial diversity and circadian alignment |
Week 2 | Add a brief daily stress practice, widen plant variety | Calms the gut brain axis and broadens the substrate range |
Week 3 and beyond | Maintain the habits, consider targeted supplement support | Converts a reset into a routine that holds |
The aim is repeatability rather than intensity. A reset delivers only if it becomes a rhythm. If you would find a ready made structure useful, our Reset Your Routine collection is a reasonable starting point.
How Long Does It Take to Reset Your Gut?
This is the question everyone actually wants answered, so here is a real timeline rather than a vague assurance. A gut health reset does not run on a fixed schedule, but the sequence is consistent enough to plan around.
Timeframe | What is happening | What you may notice |
Days 1 to 3 | Intestinal lining cells turn over rapidly while fiber begins reaching your bacteria | Reduced bloating, marginally steadier energy |
Week 1 to 2 | Microbial activity shifts in response to new substrate | More predictable digestion, diminished cravings |
Week 2 to 4 | Microbial composition begins measurably changing | Steadier regularity, less bloating, clearer energy |
Month 2 to 3 | Diversity accumulates and habits become automatic | Digestion that feels dependable rather than fortunate |
Month 3 and beyond | Resilience develops | Your gut absorbs travel, stress, and irregular weeks with less disruption |
So how long does it take to heal the gut? Days for initial relief, weeks for consistent and noticeable change, months for the diversity that makes those gains durable. The imbalance did not develop overnight, and the rebuild follows its own schedule.
Several variables determine where you land in that range: how disrupted your baseline was, whether antibiotics were recently involved, your consistency, your stress and sleep, and your starting fiber intake. Someone rebuilding after a course of antibiotics should expect a longer arc than someone recovering from a low fiber month.
Consistency outperforms intensity without exception. Eighty percent adherence sustained across two months produces substantially more than flawless execution abandoned after five days.
Where Supplements Fit: Probiotics, Prebiotics, and Fiber

Food and lifestyle come first. That hierarchy does not change. Supplements are nonetheless legitimate tools, particularly when circumstances make the ideal diet difficult to sustain. Here is where each category actually fits.
Probiotics are live beneficial microorganisms that support the balance of your microbial community.29 Labels list a CFU count, which stands for colony forming units and denotes the number of live organisms per dose. Larger is not automatically better. What matters more is the specific strain and whether that strain was studied for the outcome you are pursuing.
It also helps to know that most probiotics do not permanently colonize the gut, which is precisely why consistent daily use matters.30
During a reset, a daily formula such as UltraFlora Spectrum provides broad coverage across the digestive tract, while UltraFlora Restore is formulated for rebuilding after a disruption such as antibiotics. If your gut tends toward cramping, bloating, and unpredictability, UltraFlora IB targets that presentation.
Prebiotics are the fibers that nourish beneficial populations. If probiotics are the seed stock, prebiotics are the soil amendment. Introducing one without the other leaves the work half done.
Synbiotics combine both in a single product, so the beneficial organisms arrive alongside the substrate they preferentially consume.31 For many people that pairing is an efficient way to support the system from both directions. UltraFlora 3-in-1 is one example, combining beneficial organisms with soluble fiber in a daily powder aimed at regularity and comfort.
Fiber supplements close the distance between the fiber you intend to eat and the fiber you actually eat. MetaFiber is a straightforward daily option. Begin at a low dose, build gradually, and increase water alongside it.
Digestive enzymes operate on a different principle from everything above. Rather than supporting your bacteria, they assist in breaking down the food you consume.32 Some people find them useful for the heavy, overfull sensation after meals while the system stabilizes. SpectraZyme Complete is one option worth raising with your practitioner.
The governing principle: supplements amplify good habits rather than replacing them. If you are unsure where to begin, reviewing doctor recommended gut health supplements or the broader digestion and probiotic range alongside a conversation with your practitioner is a sensible way to narrow the field.
Keeping Your Gut Healthy After the Reset
Here is the part worth internalizing. A reset is a starting position, not a finish line. The habits that restored balance are the same ones that maintain it.
Perfection is not required. Sufficient consistency is. The habits that reset gut health in the first place are the ones that protect it over the long run. Keep the plant variety wide. Keep fermented foods in rotation. Protect sleep, move regularly, manage stress, and remain thoughtful about what you take in. Expect disrupted weeks, because holidays, travel, deadlines, and illness are features of an actual life. What has changed is that you now know the route back.
That is the quiet advantage of doing this properly. You are not merely resolving this week's bloating. You are building a system that recovers faster the next time life disrupts it.
Your gut has been underwriting your energy, your mood, and your immune function this entire time. A gut health reset is simply reciprocity. Start this week, start small, and let the system do what it is built to do.
Gut Reset Frequently Asked Questions
For most people, no. Broad elimination protocols are a clinical instrument for specific presentations, not a general wellness strategy, and removing entire food categories can reduce the very diversity you are working to build.33 Consult a practitioner before cutting anything substantial.
Some people experience a few days of additional gas or bloating when fiber increases quickly.34 That typically reflects microbial adjustment rather than something going wrong. Increasing fiber gradually and raising water intake keeps it minimal. Symptoms that are severe or persistent warrant a provider's attention.
You can support it. Maintain fiber and fermented foods, stay hydrated, and discuss probiotic timing with your provider. The substantive rebuild occurs after the course concludes, and it rewards patience.
Track functional signals rather than pursuing a number: reduced bloating, more predictable regularity, steadier afternoon energy, fewer cravings. Those everyday markers are more informative than any at home test kit currently available.
The concentrated phase, no. The underlying habits, ideally yes, most of the time. That distinction is the difference between a reset and a routine.
1. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220-230.
2. Koh A, De Vadder F, Kovatcheva-Datchary P, Backhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell. 2016;165(6):1332-1345.
3. Vighi G, Marcucci F, Sensi L, Di Cara G, Frati F. Allergy and the gastrointestinal system. Clin Exp Immunol. 2008;153(suppl 1):3-6.
4. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157(1):121-141.
5. Rowland I, Gibson G, Heinken A, et al. Gut microbiota functions: metabolism of nutrients and other food components. Eur J Nutr. 2018;57(1):1-24.
6. Cryan JF, O'Riordan KJ, Cowan CSM, et al. The microbiota-gut-brain axis. Physiol Rev. 2019;99(4):1877-2013.
7. Barker N. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat Rev Mol Cell Biol. 2014;15(1):19-33.
8. Makki K, Deehan EC, Walter J, Backhed F. The impact of dietary fiber on gut microbiota in host health and disease. Cell Host Microbe. 2018;23(6):705-715.
9. Acosta RD, Cash BD. Clinical effects of colonic cleansing for general health promotion: a systematic review. Am J Gastroenterol. 2009;104(11):2830-2836.
10. Klein AV, Kiat H. Detox diets for toxin elimination and weight management: a critical review of the evidence. J Hum Nutr Diet. 2015;28(6):675-686.
11. Sonnenburg ED, Sonnenburg JL. Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates. Cell Metab. 2014;20(5):779-786.
12. McDonald D, Hyde E, Debelius JW, et al. American Gut: an open platform for citizen science microbiome research. mSystems. 2018;3(3):e00031-18.
13. Zinocker MK, Lindseth IA. The Western diet-microbiome-host interaction and its role in metabolic disease. Nutrients. 2018;10(3):365.
14. Palleja A, Mikkelsen KH, Forslund SK, et al. Recovery of gut microbiota of healthy adults following antibiotic exposure. Nat Microbiol. 2018;3(11):1255-1265.
15. Karl JP, Hatch AM, Arcidiacono SM, et al. Effects of psychological, environmental, and physical stressors on the gut microbiota. Front Microbiol. 2018;9:2013.
16. Thaiss CA, Zeevi D, Levy M, et al. Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell. 2014;159(3):514-529.
17. Clarke SF, Murphy EF, O'Sullivan O, et al. Exercise and associated dietary extremes impact on gut microbial diversity. Gut. 2014;63(12):1913-1920.
18. Engen PA, Green SJ, Voigt RM, Forsyth CB, Keshavarzian A. The gastrointestinal microbiome: alcohol effects on the composition of intestinal microbiota. Alcohol Res. 2015;37(2):223-236.
19. Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491-502.
20. Birt DF, Boylston T, Hendrich S, et al. Resistant starch: promise for improving human health. Adv Nutr. 2013;4(6):587-601.
21. Wastyk HC, Fragiadakis GK, Perelman D, et al. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021;184(16):4137-4153.
22. McRorie JW, McKeown NM. Understanding the physics of functional fibers in the gastrointestinal tract: an evidence-based approach to resolving enduring misconceptions about insoluble and soluble fiber. J Acad Nutr Diet. 2017;117(2):251-264.
23. Oettle GJ. Effect of moderate exercise on bowel habit. Gut. 1991;32(8):941-944.
24. Voigt RM, Forsyth CB, Green SJ, Engen PA, Keshavarzian A. Circadian rhythm and the gut microbiome. Int Rev Neurobiol. 2016;131:193-205.
25. Matenchuk BA, Mandhane PJ, Kozyrskyj AL. Sleep, circadian rhythm, and gut microbiota. Sleep Med Rev. 2020;53:101340.
26. Breit S, Kupferberg A, Rogler G, Hasler G. Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders. Front Psychiatry. 2018;9:44.
27. Zaccaro A, Piarulli A, Laurino M, et al. How breath-control can change your life: a systematic review on psycho-physiological correlates of slow breathing. Front Hum Neurosci. 2018;12:353.
28. Hempel S, Newberry SJ, Maher AR, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA. 2012;307(18):1959-1969.
29. Hill C, Guarner F, Reid G, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-514.
30. Zmora N, Zilberman-Schapira G, Suez J, et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell. 2018;174(6):1388-1405.
31. Swanson KS, Gibson GR, Hutkins R, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020;17(11):687-701.
32. Ianiro G, Pecere S, Giorgio V, Gasbarrini A, Cammarota G. Digestive enzyme supplementation in gastrointestinal diseases. Curr Drug Metab. 2016;17(2):187-193.
33. Staudacher HM, Whelan K. The low-FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS. Gut. 2017;66(8):1517-1527.
34. Grabitske HA, Slavin JL. Gastrointestinal effects of low-digestible carbohydrates. Crit Rev Food Sci Nutr. 2009;49(4):327-360.

Dr. Malisa M. Carullo, ND, MSc
Naturopathic Doctor
Dr. Malisa Carullo, ND is a naturopathic doctor and serves as Senior Manager of Medical Information and Safety at Metagenics, where she supports clinical education, product safety, and evidence-based practitioner guidance across North America.
She holds a Doctorate in Naturopathic Medicine and a Master of Science in Biology, with a focus on chronic disease care, healthy aging, and evidence-based approaches to long-term wellness. Dr. Carullo is dedicated to empowering both practitioners and patients through clear, research-informed education that bridges science and everyday health decisions.




