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Liver & Detox Supplements

Support your body’s natural detox and feel renewed from within.

Liver & Detox
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26 Results

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    Support your liver health and natural detox pathways with formulas backed by science. Reset and restore balance with practitioner-trusted detox and liver supplements.

    1. UltraInflamX Plus 360°®

      Support compromised gut function from inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s.* With 26 g of plant-based protein (daily dose).

      4.5Average Rating 4.5

      Medical Food

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    2. CandiBactin-BR®

      Concentrated Berberine formula for detox, intestinal health, and digestive support.

      4.5Average Rating 4.5
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    3. Glutagenics®

      Powerful gastrointestinal lining support*

      4.8Average Rating 4.8
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    4. Clear Change® 10-Day Detox Program

      Supports the body's natural detoxification process*

      4.2Average Rating 4.2
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    5. CandiBactin-AR®

      A natural, plant-based approach to gut health, with a unique blend of concentrated essential oils and herbal extracts to support intestinal microbial balance and healthy digestion.

      4.0Average Rating 4.0
      Image of the product CandiBactin-AR®

    6. UltraClear® Renew Detox Powder

      Supports the body's natural detoxification processes with macro-and micronutrients*

      4.6Average Rating 4.6
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    7. Indole-3-Carbinol

      Supports estrogen balance.*

      4.6Average Rating 4.6
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    8. UltraClear Plus® Detox Powder

      Advanced nutritional support for metabolic detoxification.

      4.9Average Rating 4.9
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    9. Clear Change® Plus 10-Day Detox Program

      Supports the body's natural detoxification process*

      4.6Average Rating 4.6
      Image of the product Clear Change® Plus 10-Day Detox Program

    10. Renagen DTX™

      Supports kidney detox*

      5.0Average Rating 5.0
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    11. AdvaClear® Liver Health Supplement

      Daily detoxification support for balanced liver function.*

      5.0Average Rating 5.0
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    12. Golden Fusion®

      Highly bioavailable curcumin and grass-fed† collagen peptides

      5.0Average Rating 5.0
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    13. UltraClear Plus® pH Detox Powder

      Advances the body's natural detoxification plus alkalinization*

      5.0Average Rating 5.0
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    14. UltraClear® Detox Powder

      Supports liver detoxification.*

      4.3Average Rating 4.3
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    15. GlutaClear® - Glutathione Liver Support

      Supports liver detox and glutathione production*

      4.0Average Rating 4.0
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    16. Axis Endo™ Hormone Balance Supplement

      Specialized support for hormone metabolism in men and women.*

      5.0Average Rating 5.0
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    17. Clear Change® Essentials Daily Packs

      Supports body detoxification*

      5.0Average Rating 5.0
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    18. Milk Thistle Extract

      Supports healthy liver function.*

      5.0Average Rating 5.0
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    19. SulforaClear™

      Advanced sulforaphane support*

      5.0Average Rating 5.0
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    20. Clear Change® Plus pH 10-Day Detox Program

      Supports the body's natural detoxification process*

      5.0Average Rating 5.0
      Image of the product Clear Change® Plus pH 10-Day Detox Program

    21. Clear Change® Plus pH 28-Day Detox Program

      Supports the body's natural detoxification process*

      3.0Average Rating 3.0
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    22. Clear Change® 28-Day Detox Program

      Supports the body's natural detoxification process*

      Image of the product Clear Change® 28-Day Detox Program

    23. Daily Detox Support by Dr. Patricia Guevara-Channell, MD

      The ultimate detox supplement stack curated by Dr. Patricia Guevara-Channell, MD

      Price reduced to

      PracStack

      Image of the product Daily Detox Support by Dr. Patricia Guevara-Channell, MD

    24. Clear Change® Plus 28-Day Detox Program

      Supports the body's natural detoxification process*

      Image of the product Clear Change® Plus 28-Day Detox Program

    Liver & Detox Supplement Frequently Asked Questions

    The most research-supported nutrients for liver health include milk thistle (standardized to silymarin), N-acetyl cysteine (NAC), choline, alpha-lipoic acid, and B vitamins, particularly B12 and folate, which are involved in methylation and liver detoxification pathways.¹,² Selenium supports glutathione activity,³ and artichoke extract has emerging research behind it for bile production and liver enzyme support. The strongest approach combines several of these in clinically relevant doses rather than relying on a single ingredient.

    Timing depends on the specific formula. For structured detox protocols, following the product directions or a practitioner's guidance on timing and phasing is more important than a universal rule. Consistency matters more than the specific time of day.

    In most cases, yes. Standard liver support nutrients like milk thistle, NAC, and choline are well-tolerated alongside multivitamins, omega-3s, and probiotics. If you are currently taking any medications, speak with your healthcare practitioner before adding a liver supplement. They know your medical history best and can advise on what is appropriate for your individual needs.

    It depends on your health goals and individual needs. Some people use liver support supplements as part of a short-term dietary or wellness reset, while others incorporate them into a daily routine for ongoing maintenance. Either way, a healthcare practitioner is the best person to guide that decision. They can assess your health history and help you determine what duration and approach makes sense for you.

    What to Look For in a Liver Detox Supplement

    The liver performs over 500 functions, including filtering toxins from the blood, metabolizing nutrients, and producing bile for digestion.¹ Supporting those processes with the right nutrients matters. But "liver detox" is one of the most overclaimed categories in supplements. Here is what to actually look for.

    Evidence-Reviewed Ingredients

    Effective liver support rarely comes down to a single ingredient. The liver's detoxification process involves multiple pathways, and a well-formulated supplement addresses several of them at once. Milk thistle (silymarin) is one of the most studied botanicals in liver health, with research supporting its role in liver cell protection and normal liver enzyme activity.²,³ NAC supports glutathione production, the liver's primary antioxidant. Choline plays a direct role in fat metabolism within the liver. B vitamins support methylation pathways involved in phase II detoxification.

    Each ingredient has a specific role, and together they provide more comprehensive support than any one compound can on its own. Metagenics detox formulas are built around this multi-pathway approach, combining evidence-reviewed ingredients at clinically informed doses.

    Transparent Labeling and Dosing

    Seeing "milk thistle extract" on a label means little without knowing the silymarin standardization percentage and milligram dose. Effective liver supplements disclose exactly what is in each serving and at what concentration.

    Metagenics products are fully labeled with clinically informed doses, not token amounts included to check a box.

    Practitioner-Grade Manufacturing Standards

    Liver supplements are often taken as part of a structured protocol. Manufacturing quality, purity testing, and absence of contaminants are non-negotiable in that context. Metagenics formulas meet pharmaceutical-grade manufacturing standards and are verified for potency and purity.

    Fit for Your Specific Goal

    There is a difference between daily liver maintenance support and a structured short-term protocol designed around dietary changes. Understanding what you are trying to accomplish helps narrow which product type is appropriate. A practitioner can help match the right formula to the right context, particularly if liver enzymes or other markers are involved.

    The Benefits of Supplements for Detox & Liver Support

    The liver is the body's primary filtration organ. It processes everything from environmental exposures and alcohol to medications and metabolic byproducts. When nutritional gaps exist, that workload becomes harder to manage efficiently. Targeted supplementation helps fill those gaps.

    Supporting Glutathione Production

    Glutathione is often called the body's master antioxidant. The liver both produces and relies on it to neutralize harmful compounds during detoxification. NAC, glycine, and selenium are precursors that support glutathione synthesis. When these nutrients are consistently available, the liver's phase II detoxification pathways function more efficiently.

    Protecting Liver Cells

    Silymarin, the active compound in milk thistle, has been shown to support liver cell membrane integrity and normal liver enzyme levels in research settings. It is one of the most studied plant compounds in hepatic health and a cornerstone ingredient in practitioner-recommended liver formulas.

    Supporting Fat Metabolism in the Liver

    For people who do not consume enough choline through diet (eggs and liver are the primary sources), looking for formulas that include choline as part of a comprehensive liver support protocol is a practical way to close that gap.

    That keeps the educational value intact, stays compliant, and does not imply a product Metagenics does not carry.

    References

    1. Johns Hopkins Medicine. Liver: Anatomy and Functions. https://www.hopkinsmedicine.org/health/conditions-and-diseases/liver-anatomy-and-functions

    2. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010;24(10):1423-1432. doi:10.1002/ptr.3207

    3. Abenavoli L, Izzo AA, Milic N, et al. Milk thistle (Silybum marianum): a concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother Res. 2018;32(11):2202-2213. doi:10.1002/ptr.6171