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Immune Support Supplements

Support your immune defenses with supplements you can trust.

Immune Health
64 Results
64 Results

  • All Products (228)
  • Brain & Cognitive Health (31)
  • Bundle & Save (8)
  • Digestion & Probiotics (51)
  • Essential Wellness (73)
  • Heart Health (48)
  • Immune Health (64)
  • Kid's Health (7)
  • Liver & Detox (26)
  • Magnesium (14)
  • Men's Health (13)
  • Omega-3s & Fish Oil (14)
  • Pain, Bone & Joint (41)
  • Protein & Sports Nutrition (27)
  • Sleep (20)
  • Stress, Mental Health (42)
  • Vitamins & Minerals (45)
  • Weight Management (43)
  • Women's Health (43)

    Support your immune health with targeted vitamins, probiotics, and antioxidants. Science-backed formulas designed to help maintain healthy immune function and provide year-round wellness support.

    1. PhytoMulti® Multivitamin

      Science-backed multivitamin for daily cellular health and overall wellness*

      4.8Average Rating 4.8

      Best Seller

      Image of the product PhytoMulti® Multivitamin

    2. UltraFlora® Complete Probiotic

      Our most comprehensive probiotic: complete gut, immune, skin health, and more*

      4.6Average Rating 4.6
      Image of the product UltraFlora® Complete Probiotic

    3. PhytoMulti® Multivitamin Capsules

      Plant-based daily multivitamin for energy, brain, and immune support

      4.6Average Rating 4.6

      Best Seller

      Image of the product PhytoMulti® Multivitamin Capsules

    4. UltraFlora® Women's Probiotic

      Daily probiotic support for vaginal, urinary, and gut microbiome balance

      4.5Average Rating 4.5

      Best Seller

      Image of the product UltraFlora® Women's Probiotic

    5. UltraFlora® Balance Probiotic

      Daily probiotic for gut balance, digestive comfort, and immune support

      4.7Average Rating 4.7

      Best Seller

      Image of the product UltraFlora® Balance Probiotic

    6. PhytoMulti® Superfoods

      Organic superfood powder for digestive and immune support.*

      4.5Average Rating 4.5
      Image of the product PhytoMulti® Superfoods

    7. UltraFlora® 3-in-1 Daily Probiotic

      Synbiotic (probiotics + prebiotic) for gut and immune health

      4.5Average Rating 4.5
      Image of the product UltraFlora® 3-in-1 Daily Probiotic

    8. UltraFlora® Spectrum Probiotic

      Broad-spectrum probiotic for upper and lower GI support, digestive comfort, and immunity

      4.7Average Rating 4.7
      Image of the product UltraFlora® Spectrum Probiotic

    9. SPM Active® One Daily

      Eases soreness and supports joint health in as little as 2 weeks.*

      4.5Average Rating 4.5
      Image of the product SPM Active® One Daily

    10. UltraFlora® BiomePro Probiotic

      Supports gut, immune, and respiratory health*

      4.6Average Rating 4.6
      Image of the product UltraFlora® BiomePro Probiotic

    11. UltraGI Replenish®

      Support for the management of compromised gut function with digestive disorders including malabsorption

      4.6Average Rating 4.6

      Medical Food

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    12. Immune Active™

      Immune system support*

      4.4Average Rating 4.4
      Image of the product Immune Active™

    13. Ultra Potent-C® 500 Vitamin C

      High-potency formula to support immune health. Gentle on the stomach.*

      4.6Average Rating 4.6
      Image of the product Ultra Potent-C® 500 Vitamin C

    14. UltraInflamX Plus 360°®

      Support compromised gut function from inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s.* With 26 g of plant-based protein (daily dose).

      4.5Average Rating 4.5

      Medical Food

      Image of the product UltraInflamX Plus 360°®

    15. Ultra Potent-C® 1000 Vitamin C

      High-potency buffered vitamin C for daily immune and antioxidant support. Stomach-friendly formulation.*

      4.8Average Rating 4.8
      Image of the product Ultra Potent-C® 1000 Vitamin C

    16. SPM Active®

      Targets the root causes of body soreness*

      4.4Average Rating 4.4
      Image of the product SPM Active®

    17. CandiBactin-BR®

      Concentrated Berberine formula for detox, intestinal health, and digestive support.

      4.5Average Rating 4.5
      Image of the product CandiBactin-BR®

    18. Glutagenics®

      Powerful gastrointestinal lining support*

      4.8Average Rating 4.8
      Image of the product Glutagenics®

    19. Clear Change® 10-Day Detox Program

      Supports the body's natural detoxification process*

      4.2Average Rating 4.2
      Image of the product Clear Change® 10-Day Detox Program

    20. CandiBactin-AR®

      A natural, plant-based approach to gut health, with a unique blend of concentrated essential oils and herbal extracts to support intestinal microbial balance and healthy digestion.

      4.0Average Rating 4.0
      Image of the product CandiBactin-AR®

    21. Multigenics® Multivitamin

      Broad spectrum vitamin and mineral formula to support overall health.*

      4.7Average Rating 4.7
      Image of the product Multigenics® Multivitamin

    22. Zinc A.G.™

      Supports immune health.*

      4.7Average Rating 4.7
      Image of the product Zinc A.G.™

    23. UltraClear® Renew Detox Powder

      Supports the body's natural detoxification processes with macro-and micronutrients*

      4.6Average Rating 4.6
      Image of the product UltraClear® Renew Detox Powder

    24. Ultra Potent-C® Chewable Vitamin C

      High-potency formula to support immune health. Gentle on the stomach.*

      4.9Average Rating 4.9
      Image of the product Ultra Potent-C® Chewable Vitamin C

    Immune System Support Supplements Frequently Asked Questions

    The most well-researched immune support nutrients include vitamin C, vitamin D, zinc, and selenium. These micronutrients play direct roles in white blood cell production, immune cell signaling, and the body's normal inflammatory response. Probiotics support the gut-immune axis, the connection between your digestive microbiome and immune function. A comprehensive immune supplement protocol often combines several of these rather than relying on a single ingredient.

    Certain vitamins are best known for supporting immune health, including vitamin C, vitamin D, and B vitamins. Vitamin C helps support normal immune cell function and antioxidant protection, while vitamin D plays an important role in regulating healthy immune responses. B vitamins, including B6 and B12, help support energy production and overall immune function. Because nutritional needs vary from person to person, a healthcare practitioner can help identify which nutrients are most relevant for your individual health needs.

    Yes. A large portion of the immune system is connected to the digestive tract, which is why gut health plays an important role in overall immune health.⁵ The bacteria that naturally live in the gut, known as the gut microbiome, help support normal immune function and communicate with immune cells throughout the body.

    Factors like stress, poor diet, travel, illness, and antibiotic use can disrupt gut balance over time. Supporting gut health with probiotics, fiber-rich foods, and daily digestive wellness habits may help maintain a healthy microbiome and support immune system function year-round.

    Nutrients like vitamin D, zinc, and probiotics are designed for consistent daily use and are well-tolerated at recommended doses. That said, more isn't always better.

    Following label dosing and periodic check-ins with a healthcare practitioner, especially if you're taking multiple supplements, is the most straightforward way to make sure your routine stays safe and appropriate for your individual needs.

    Many immune support supplements, including vitamin D, zinc, probiotics, and antioxidants, are formulated for daily use and are generally well-tolerated when used as directed. Consistent intake of key nutrients can help support normal immune function and overall wellness. However, more is not always better.

    Following label directions and speaking with a healthcare practitioner can help ensure your immune health supplement routine is appropriate for your individual needs, especially if you take multiple supplements or medications.

    Immunity Boosting Supplements for Year-Round Defense

    Support healthy immune function year-round with targeted vitamins, minerals, probiotics, antioxidants, and botanicals. Your immune system never takes a day off, and consistent nutritional support helps give it what it needs to keep working. Metagenics immune formulas are science-backed and built around nutrients with a meaningful research history in immune health.

    Vitamin C and Zinc

    Two of the most studied nutrients in immune health. Vitamin C supports the production and function of white blood cells, while zinc plays a central role in immune cell development and the body's normal inflammatory response. Both are commonly depleted by stress, poor diet, and intense physical activity.

    Vitamin D

    Vitamin D receptors are found on nearly every immune cell. Adequate vitamin D levels are associated with normal immune system regulation, yet deficiency is widespread, particularly in northern climates and among people who spend most of their time indoors. Supplementing helps fill that gap year-round.

    Probiotics and Gut-Immune Connection

    Roughly 70% of the immune system is housed in the gut. The beneficial bacteria that live there communicate directly with immune cells, helping to calibrate the body's defenses. A high-quality probiotic supports that ecosystem, which in turn supports immune readiness.

    Botanicals and Plant-Based Support

    Certain plant-based compounds have a documented research history in immune health. When combined with key micronutrients, evidence-reviewed botanicals can provide an additional layer of support for the body's normal immune response. Metagenics immune formulas are built around this integrated approach, combining targeted nutrients with plant-based compounds selected for their research background, not just their marketing appeal.

    How to Choose the Right Immune Support Supplement

    The immune supplement category is crowded. Here's what actually separates a well-formulated product from a label full of claims.

    Look for Clinically Relevant Doses

    Effective supplements for immunity support deliver nutrients at amounts that research supports, not just enough to list the ingredient. Check the supplement facts panel, not just the front of the bottle.

    Consider Your Baseline Gaps

    Immune support isn't one-size-fits-all. Someone who eats a varied diet and gets regular sun exposure has different gaps than someone under chronic stress with limited vegetable intake. A practitioner-guided approach helps match supplementation to what your immune system actually needs.

    Prioritize Purity and Manufacturing Standards

    Metagenics products are manufactured to pharmaceutical-grade standards, with third-party testing for contaminants and potency verification. For immune system support supplements you're taking daily, sourcing and manufacturing quality matter as much as the ingredients themselves.

    Think Year-Round, Not Just Seasonal

    The immune system doesn't take summers off. Consistent, daily supplementation builds the nutritional foundation that supports immune readiness over time, rather than reactive dosing when you're already feeling run down.