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ADVANCED PROBIOTICS & GUT SUPPLEMENTS

When your digestion is off, everything is off.

Don't just mask symptoms. Build a resilient gut with the UltraFlora® system. Clinically studied probiotics, fiber, and targeted support so you feel lighter, more regular, and back to yourself.*

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  • Icon of a supplement bottle with text stating ‘Over 25 million bottles sold’ +25 million bottles sold
  • Medical cross icon with text stating ‘Trusted by more than 50,000 doctors’ Trusted by +50K doctors
  •  Checkmark badge icon with text stating ‘Third‑party verified for purity’ Third-party verified for purity
  • Dollar sign icon with text stating ‘Money‑back guarantee’ Money-back guarantee
Testimonials

3 Reasons Why Your Gut is Off Right Now

Most gut problems don’t appear overnight. They build slowly from everyday patterns. Here are the three biggest drivers of digestive discomfort:
  • A person smiling while preparing a cutting board full of fresh vegetables, illustrating the importance of fiber intake for gut health. Part of a webpage discussing doctor recommended probiotics and how daily habits influence digestion.

    You’re not getting enough fiber

    Most adults get half the 30g fiber we need daily, but your gut craves more. Shop Fiber Supplements
  • eople reaching into a bowl of chips during a late-night snack, representing how heavy or late meals can disrupt sleep and digestion. Featured on a page about doctor recommended probiotics and lifestyle factors that affect gut health.

    Heavy meals disrupt your sleep

    Eating too much or too late keeps your gut on when rest & reset should start. Shop Nighttime Support
  • A person sitting cross‑legged on a couch with hands on their stomach and chest, practicing a calming breathing exercise to support gut balance. Used on a page explaining how stress impacts digestion and the role of doctor recommended probiotics.

    Your microbiome is off balance

    Stress, travel, inactivity, & overeating can keep gut balance out of sync. Shop Gut Balance
Pick Your Path

What do you want your gut routine to do for you?

Whether you're building your daily gut support ritual or targeting specific digestive concerns, the UltraFlora® collection offers clinically studied solutions designed for real life.
Build a Gut Routine

Build a gut routine that works with your day and night.

UltraFlora® now offers two new ways to support digestion as part of your daily rhythm:

daytime sun
Daytime
Digestive Support

Supports daily consistency and gut balance*

A hand holding a white bottle of Metagenics UltraFlora® Fiber + Prebiotic + Probiotic, a daytime formula designed to support daily consistency and gut balance. Featured on a page about doctor recommended probiotics.
nighttime
Nighttime
Digestive Comfort

Supports digestion while you sleep*

A hand holding a bottle of Metagenics  UltraFlora® Night Rest & Digest Probiotic, a nighttime formula that supports digestion while you sleep. Included in content discussing doctor recommended probiotics.
Your Solution
A BETTER DAILY FIBER SUPPLEMENT

Finally, fiber that doesn't fight back

Other fiber supplements stop at regularity. UltraFlora® Fiber, Prebiotic & Probiotic goes further: 4g of fiber plus clinically studied pre- & probiotics, dissolved clear in any liquid.*

A single‑serve packet of Metagenics UltraFlora® Fiber + Prebiotic + Probiotic, shown with some of the orange‑citrus powder spilled beside it to highlight the product’s texture. Featured on a page about doctor recommended probiotics and daily fiber support.
What makes ULTRAFLORA® FIBER different
  • A white icon representing gentle daily fiber support, used in content about doctor recommended probiotics.

    4 g Gentle fiber

    Supports regularity without bloating or thick texture common in fiber drinks.*

  • A white icon symbolizing prebiotics that nourish beneficial gut bacteria, featured on a page about doctor recommended probiotics.

    Prebiotics

    Feeds your good bacteria for digestion, nutrient absorption, & immunity.*

  • A white icon depicting live probiotic strains that support digestion and immunity, included in content discussing doctor recommended probiotics.

    Probiotics

    Live strains clinically studied to support digestion, immunity & whole-body health.*

IDEAL FOR:
  • An icon representing a high‑protein diet, shown in a section about doctor recommended probiotics. High-protein diets
  •  An icon symbolizing stress and its impact on digestion, featured on a page discussing doctor recommended probiotics. Stress
  • A travel‑related icon indicating digestive support for people on the go, included in content about doctor recommended probiotics. Traveling
  • An icon representing gut support for individuals using GLP‑1 therapies, featured alongside advanced gut health supplements. GLP-1 users*
  • An icon symbolizing daily digestive regularity, used in a section highlighting doctor recommended probiotics. Anyone seeking daily regularity
Try UltraFlora® Fiber
Your Solution
NIGHTTIME INDIGESTION SUPPORT

Your solution for better digestion and deeper sleep

Indigestion keeping you awake? If so, your gut is still working, but your body wants rest. UltraFlora® Night Rest & Digest uses clinically studied postbiotics to support overnight digestion — so you sleep soundly and wake up feeling fresh.*

 A woman sleeping peacefully in bed, used to illustrate nighttime digestive comfort supported by doctor recommended probiotics.
WHAT MAKES NIGHTTIME SUPPORT DIFFERENT
  • A white icon representing targeted postbiotic strains that support nighttime digestion, featured on a page about doctor recommended probiotics.

    Targeted postbiotic strains

    Clinically studied postbiotics that support digestion and gut comfort in bed.*

  • A white icon symbolizing an evening routine, indicating digestive support after dinner, included in content about doctor recommended probiotics.

    Made for evening routines

    Supports digestive balance after dinner so your body can easily shift into rest-mode.*

  • A white apple‑shaped icon representing gut support without antacids or melatonin, featured on a page about doctor recommended probiotics.

    No antacids or melatonin

    Supports your gut microbiome directly instead of just masking symptoms.*

PERFECT FOR:
  • An icon representing gut support for individuals using GLP‑1 therapies, featured alongside advanced gut health supplements. GLP-1 users*
  • An icon symbolizing relief from bloating, included in content about doctor recommended probiotics. Bloating
  • A flame‑style icon representing digestive burning or discomfort, used on a page discussing doctor recommended probiotics. Burning
  • An icon depicting upper‑digestive belching discomfort, featured in content about doctor recommended probiotics. Belching
  • An icon symbolizing post‑meal fullness, included on a page about doctor recommended probiotics. Fullness
  • An icon representing digestive support after heavy meals, featured in content discussing doctor recommended probiotics. Heavy meals
Try Night Rest & Digest
Why Metagenics

The UltraFlora® difference:

Not your average probiotics
For +40 years, Metagenics® has partnered with doctors to create supplements rooted in science, quality, and results. Our advanced probiotics were once available only through doctor's offices — and today UltraFlora® remains one of the most trusted brands in gut health.
  • An icon of a supplement bottle with pills, symbolizing fast‑acting digestive support, featured on a page about doctor recommended probiotics. Starts working in 30 mins
  •  A clock icon indicating 24‑hour digestive support, featured on a page about doctor recommended probiotics. Stays active for 24 hours
  •  A clipboard icon with a checkmark symbolizing probiotic strains that survive stomach acid, featured on a page about doctor recommended probiotics. Survives stomach acid
  • An icon of stacked documents symbolizing shelf‑stable probiotic strains, featured on a page about doctor recommended probiotics. Shelf-stable strains
Why Metagenics
Testimonials

Real People. Real Gut Transformations.

  • A single stick pack of UltraFlora Fiber in orange flavor, featured on a page about doctor recommended probiotics.
    "I've been using it for a few weeks now and I'm really impressed with the results. My digestion and overall gut health has improved, and I found I have more energy throughout the day. The taste is pleasant, not chalky or overly sweet and blends smoothly into water without a gritty texture."
    five gold stars Ricky Shop UltraFlora® Fiber
  •  A green capsule pill icon representing a dietary supplement, featured on a page about doctor recommended probiotics.
    “I really like this product. I tend to eat dinner pretty late, so I’ve been taking this before bed. I’ve been finding that my stomach feels settled and way less bloated in the morning. I’m a big fan of probiotics as is, and to add postbiotics feels awesome.”
    five gold stars Meghan Shop Night Rest & Digest
  • A brown glass bottle of Metagenics UltraFlora Balance Probiotic held between two hands, featured on a page about doctor recommended probiotics.
Explore Our Products

Listen to your gut—it’s calling for UltraFlora®

Think about your gut the same way you think about your teeth. You don’t wait for a cavity before brushing — you do it to prevent problems. Your gut needs the same daily support.
  • All
  • Probiotics
  • Probiotics +
  • Postbiotics
  • Akkermansia
  • Herbal Support
  • Regularity
    A container of Metagenics UltraFlora Fiber prebiotic and probiotic powder, featured on a page about doctor recommended probiotics.
    Triple-action, gentle fiber supplement powder
    UltraFlora® Fiber, Prebiotic & Probiotic
    $32.95
    4.2 star
    SHOP NOW
  • Indigestion
    A bottle of Metagenics UltraFlora Night Rest & Digest postbiotic capsules, featured on a page about doctor recommended probiotics.
    Supports digestion & gut comfort while you rest
    UltraFlora® Night Rest & Digest
    $34.95
    4.7 star
    SHOP NOW
  • Women’s Health
    A bottle of Metagenics UltraFlora Complete Women’s Probiotic, featured on a page about doctor recommended probiotics.
    Vaginal, urinary, gut, mood & immune support
    UltraFlora® Complete Women’s Probiotic
    $39.95
    4.6 star
    SHOP NOW
  • Gut Essential
    A bottle of Metagenics UltraFlora Balance Probiotic, featured on a page about doctor recommended probiotics.
    Support digestion, immunity & microbiome
    UltraFlora® Balance Probiotic
    $24.95
    4.7 star
    SHOP NOW
  • Weight
    A bottle of Metagenics UltraFlora Healthy Weight with Akkermansia, featured on a page about doctor recommended probiotics.
    Supports healthy weight maintenance
    UltraFlora® Healthy Weight with Akkermansia
    $69.95
    4.2 star
    SHOP NOW
  • Synbiotic Care
    A bottle of Metagenics UltraFlora Triplebiotic with pre‑, pro‑, and postbiotics, featured on a page about doctor recommended probiotics.
    Daily prebiotic, probiotic, and postbiotic
    UltraFlora® Triplebiotic
    $54.95
    4.4 star
    SHOP NOW
  • Vaginal Health
    A bottle of Metagenics UltraFlora Women’s Probiotic, featured on a page about doctor recommended probiotics.
    Vaginal, urinary, and gut microbiome balance
    UltraFlora® Women’s Probiotic
    $36.95
    4.5 star
    SHOP NOW
  • Intestine Care
    A bottle of Metagenics CandiBactin‑AR dietary supplement, featured on a page about doctor recommended probiotics.
    Supports a healthy intestine & respiratory tract
    CandiBactin-AR®
    $52.95
    3.9 star
    SHOP NOW
  • Detox
    A bottle of Metagenics CandiBactin‑BR dietary supplement, featured on a page about doctor recommended probiotics
    Supports detoxification & intestinal health
    CandiBactin-BR®
    $52.95
    4.5 star
    SHOP NOW
  • Full GI Care
    A bottle of Metagenics UltraFlora Spectrum Probiotic, featured on a page about doctor recommended probiotics.
    Multi-strain probiotic for GI and immune health
    UltraFlora® Spectrum Probiotic
    $51.95
    4.7 star
    SHOP NOW
  • +Multivitamins
    A bottle of Metagenics UltraFlora Probiotic + Multivitamin, featured on a page about doctor recommended probiotics.
    Calm your overactive gut & support digestion
    UltraFlora® Probiotic + Multivitamin
    $29.95
    4.5 star
    SHOP NOW
  • Complete Care
    A bottle of Metagenics UltraFlora Complete Probiotic, featured on a page about doctor recommended probiotics.
    9-in-1 probiotic for gut & whole body balance
    UltraFlora® Complete Probiotic
    $39.95
    4.6 star
    SHOP NOW
  • Pre + Pro Gummy
    A bottle of Metagenics UltraFlora 3in1 Daily Probiotic gummies, featured on a page about doctor recommended probiotics.
    Delicious chewables for gut & immune health
    UltraFlora® 3-in-1 Daily Probiotic Gummies
    $29.95
    4.5 star
    SHOP NOW
  • Reset + Restore
    A Daily Gut Health Bundle featuring Metagenics CandiBactin‑BR and UltraFlora Balance Probiotic, shown together on a page about doctor recommended probiotics.
    Detox, reset, and restore your gut microbiome
    Daily Gut Health Bundle
    $54.53
    $77.90
    5.0 star
    SHOP NOW
  • Upset Gut
    A Gut Relief Duo for Occasional Bowel Distress bundle featuring Metagenics UltraFlora Acute Care Probiotic and SpectraZyme Pancreatic Enzymes Extra Strength, shown on a page about doctor recommended probiotics.
    Calm an overactive gut & support digestion
    Gut Relief Duo for Occasional Bowel Distress
    $73.65
    $105.20
    4.5 star
    SHOP NOW
Gut Health Quiz Banner
Close-up of a woman in athletic leggings with midriff exposed, leaning against a kitchen countertop beside a stainless steel water bottle and a glass bottle of Metagenics UltraFlora® Complete Women's Probiotic. The focus on her core emphasizes gut health and an active, wellness-oriented lifestyle, reinforcing the value of personalized probiotic support.

Find Your Match in 2 Mins

Have you ever used gut health supplements?

Common questions about digestion, fiber, and probiotics

Many fiber supplements use bulking agents that absorb water rapidly and ferment in the gut, producing gas. If you’ve experienced this, it doesn’t mean fiber isn’t for you—it means the type of fiber matters. UltraFlora® Fiber uses a gentle formula designed for daily comfort without the bloating that makes people quit fiber altogether.

A good baseline is 2-3 liters per day, especially when increasing fiber intake. Water helps fiber move through your digestive system effectively. Without it, fiber can slow things down rather than help—which is the opposite of what you want.

Start low and go slow. GLP-1 medications already slow gastric emptying, so adding too much fiber too fast can increase discomfort. Choose a gentle, non-bloating fiber (like UltraFlora® Fiber) and pair it with adequate hydration. Many practitioners recommend fiber as the first dietary adjustment for GLP-1 users—but always confirm with your prescribing provider.

When you lie down, gravity stops helping your digestive system move food through. Combine that with a large or late meal, and your stomach has to work harder in a position that makes reflux and discomfort more likely. That’s why nighttime indigestion often disrupts sleep—and why targeted overnight support can help.

Not all of them. UltraFlora® products are shelf-stable—no refrigeration required. We do extensive quality testing to guarantee the CFU count shown on the label through expiration. Just follow the storage instructions on the label.

No. What matters is whether the strains are clinically studied at the dose provided. A 100-billion-CFU label might look impressive, but if those strains haven’t been researched at that level, the number is marketing. UltraFlora® includes the clinically validated dose for each strain—nothing more, nothing less.

Signs to look for: more regular digestion, less bloating, fewer stomach issues, and sometimes improved mood or skin. Effects are typically gradual—a few days to a few weeks. If you’re not sure, keep a simple daily log of how you feel. Patterns become clear quickly.

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