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Specialized pro-resolving mediators (SPMs) are molecules our bodies produce naturally in response to damaged tissue due to physical challenges and are a critical component of the body’s natural healing process. Unfortunately, the body may not produce enough SPMs on its own. Diet, lifestyle, excess body fat, and other health challenges can affect SPM production. That’s where our clinically studied SPM Active can help.*
The human body is equipped with a natural defense called the immune system, which is designed to fight off external threats and damaged tissue caused by these threats and help the body return to homeostasis. Although the immune response is a natural process, it can be harmful to the body if left unresolved.
The immune response ideally occurs in two phases: initiation and resolution. When a person experiences a physical challenge, lipid mediators and various other compounds are produced naturally in the body. This is called initiation and is marked by physical discomfort and other physical responses.1
During resolution, pro-resolving lipid mediators are produced and help the body to heal and repair itself naturally. Unfortunately, inadequate SPM production can hinder the body’s natural recovery process—leaving the immune response incomplete and unresolved.2
While scientists traditionally believed that resolution was a passive process, groundbreaking research has shown that resolution is an active process that’s dependent on adequate SPM status.3*
Through collaboration and research with top-level scientists, we were the first to introduce SPMs to the market in 2015.
Over four years, we’ve demonstrated activity of our SPM Active formula and conducted six clinical interventions to discover the potential for SPMs to positively impact human health.
Metagenics invested in the first intervention study with SPM standardized dietary supplement.5
SPMs encourage immune cells to be more protective and less likely to amplify the negative effects of an environmental stressor.*
SPMs are necessary to return to homeostasis after a physical challenge and support overall wellbeing.*
SPM resolution activities play a role in the body’s ability to bounce back from environmental challenges.*
1. Serhan CN. Mol Aspects Med. 2017;58:1-11.
2. Serhan CN. FASEB J. 2017;31(4):1273-1288.
3. Dalli J et al. Br J Pharmacol. 2019;176(8):1024-1037.
4. Serhan CN. Nature. 2014;510(7503):92-101.
5. Souza PR et al. Circ Res. 2020;126(1):75-90.
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Dianne from Jackson County Michigan