SPM Active®

Specialized pro-resolving mediators
SPM Active®
SPM Active®
SPM Active is designed to help support the body’s natural capacity to respond to physical challenges and resolve the immune response.*

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Serving size: 2 Softgels
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Product Information Sheet
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Specialized pro-resolving mediators (SPMs) are molecules our bodies produce naturally in response to damaged tissue due to physical challenges and are a critical component of the body’s natural healing process. Unfortunately, the body may not produce enough SPMs on its own. Diet, lifestyle, excess body fat, and other health challenges can affect SPM production. That’s where our clinically studied SPM Active can help.*

SPMs have been known to support individuals experiencing:
Physical discomfort from everyday activities
Physical discomfort from everyday activities*
Exercise-related discomfort
Reduced SPM production linked to excess body fat
Reduced SPM production linked to excess body fat*

To address the immune response, we first need to define it.

The human body is equipped with a natural defense called the immune system, which is designed to fight off external threats and damaged tissue caused by these threats and help the body return to homeostasis. Although the immune response is a natural process, it can be harmful to the body if left unresolved.

Defining the immune response
Immune response initiation

In a perfect world, the immune response should resolve itself.

The immune response ideally occurs in two phases: initiation and resolution. When a person experiences a physical challenge, lipid mediators and various other compounds are produced naturally in the body. This is called initiation and is marked by physical discomfort and other physical responses.1


But SPM production may be lacking.

During resolution, pro-resolving lipid mediators are produced and help the body to heal and repair itself naturally. Unfortunately, inadequate SPM production can hinder the body’s natural recovery process—leaving the immune response incomplete and unresolved.2

SPM production may be lacking
Role of specialized pro-resolving mediators
Role of specialized pro-resolving mediators

That’s where SPM Active can help.

While scientists traditionally believed that resolution was a passive process, groundbreaking research has shown that resolution is an active process that’s dependent on adequate SPM status.3*

Initiation to resolution
SPMs initiation to resolution infographic
Why choose ours?

We were the first.

Through collaboration and research with top-level scientists, we were the first to introduce SPMs to the market in 2015.

We've done our homework.

Over four years, we’ve demonstrated activity of our SPM Active formula and conducted six clinical interventions to discover the potential for SPMs to positively impact human health.

We expand the boundaries of nutritional science

Metagenics invested in the first intervention study with SPM standardized dietary supplement.5

The role of SPMs in the body
Reprogram immune cells
Reprogram immune cells

SPMs encourage immune cells to be more protective and less likely to amplify the negative effects of an environmental stressor.*

Help restore balance
Help restore balance

SPMs are necessary to return to homeostasis after a physical challenge and support overall wellbeing.*

Support resilience
Support resilience

SPM resolution activities play a role in the body’s ability to bounce back from environmental challenges.*


Clinical Summary

Clinical Summary

SPM Active Formula Focus Sheet

Formula Focus Sheet

The SPM Difference

The SPM Difference



1. Serhan CN. Mol Aspects Med. 2017;58:1-11.
2. Serhan CN. FASEB J. 2017;31(4):1273-1288.
3. Dalli J et al. Br J Pharmacol. 2019;176(8):1024-1037.
4. Serhan CN. Nature. 2014;510(7503):92-101.
5. Souza PR et al. Circ Res. 2020;126(1):75-90.


Label & Supplement Facts

Average Customer Rating: (3 Reviews) This item can be reviewed only by verified buyers

These reviews have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Great Product

A few years ago my knees were so sore I was having a hard time walking. I was so blessed to find a chiropractor that recommended your SPM product. It has been a life saver for me. Knees get sore from time to time, but much more manageable. Thank you for such a great product and the great service.

2 of 2 people found this review helpful. Do you? yes no  Certified buyer

Spm active

I love all the products I use from metagenics.

0 of 1 people found this review helpful. Do you? yes no  Certified buyer

SPM Active

My doctor, Kelly McCann MD, in Newport Beach recommended this product several years ago. I have taken it ever since. I think it is far superior to regular fish oil capsules.

Did you find this review useful? yes no  Certified buyer