SPM Active® for Body and Joint Support*

5.0

(34 reviews)

Targets root causes of soreness for lasting relief*†

SPM Active® Supplement 120 ct new label vs old label

Metagenics SPM Active® supplement facts – 120 count

Metagenics SPM Active targets root causes of soreness by supporting the body’s natural ability to soothe discomfort*

Metagenics SPM Active difference in two weeks*††

A few years ago my knees were sore and I had hard time walking. SPM has been a life saver. Knees get sore periodically, but more manageable.

Dianne

SPM Active® is designed to support the body’s natural ability to soothe and minimize discomfort. Formulated with next-generation omega fish oil to provide long lasting comfort.*†

Helps with joint soreness and discomfort intensity in two weeks*††
First and only SPM supplement with clinically published research and demonstrated results for mild pain*
Money back guarantee

†Based on loading dose with 2g SPM Active daily for 6 weeks

††36% of clinical study participants reported decreased soreness and discomfort after 2 weeks of supplementation with 1.5 g SPM Active daily. Callan N, et al. J Transl Med. 2020;18(1):401.

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Serving size, 2 Softgels.

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A few years ago my knees were sore and I had hard time walking. SPM has been a life saver. Knees get sore periodically, but more manageable.

Dianne

Benefits of SPM Active

Specialized pro-resolving mediators (SPMs) are molecules our bodies produce naturally in response to damaged tissue due to physical challenges and are a critical component of the body’s natural healing process. Unfortunately, the body may not produce enough SPMs on its own. Diet, lifestyle, excess body fat, and other health challenges can affect SPM production. That’s where our clinically studied SPM Active can help.*

SPMs have been known to support individuals experiencing:

Physical discomfort from everyday activities*

Exercise-related
discomfort*

Reduced SPM production linked to excess body fat*

To address the immune response, we first need to define it.

The human body is equipped with a natural defense called the immune system, which is designed to fight off external threats and damaged tissue caused by these threats and help the body return to homeostasis. Although the immune response is a natural process, it can be harmful to the body if left unresolved.

INITIATION

In a perfect world, the immune response should resolve itself.

The immune response ideally occurs in two phases: initiation and resolution. When a person experiences a physical challenge, lipid mediators and various other compounds are produced naturally in the body. This is called initiation and is marked by physical discomfort and other physical responses.¹

RESOLUTION

But SPM production may be lacking.

During resolution, pro-resolving lipid mediators are produced and help the body to heal and repair itself naturally. Unfortunately, inadequate SPM production can hinder the body’s natural recovery process—leaving the immune response incomplete and unresolved.²

Role of specialized pro-resolving mediators

ROLE OF SPECIALIZED PRO-SOLVING MEDIATORS

That’s where SPM Active can help.

While scientists traditionally believed that resolution was a passive process, groundbreaking research has shown that resolution is an active process that’s dependent on adequate SPM status.³*

Initiation to resolution

Why choose SPM Active?

We were the first.

Through collaboration and research with top-level scientists, we were the first to introduce SPMs to the market in 2015.

We've done our homework.

Over four years, we’ve demonstrated activity of our SPM Active formula and conducted six clinical interventions to discover the potential for SPMs to positively impact human health.

We expand the boundaries of nutritional science

Metagenics invested in the first intervention study with SPM standardized dietary supplement.⁵

Learn More

The role of SPMs in the body

Reprogram immune cells

SPMs encourage immune cells to be more protective and less likely to amplify the negative effects of an environmental stressor.*

Help restore balance

SPMs are necessary to return to homeostasis after a physical challenge and support overall wellbeing.*

Support resilience

SPM resolution activities play a role in the body’s ability to bounce back from environmental challenges.*

Resources

Clinical Summary

Download

Formula Focus Sheet

Download

The SPM Difference

Download

References

1. Serhan CN. Mol Aspects Med. 2017;58:1-11.
2. Serhan CN. FASEB J. 2017;31(4):1273-1288.
3. Dalli J et al. Br J Pharmacol. 2019;176(8):1024-1037.
4. Serhan CN. Nature. 2014;510(7503):92-101.
5. Souza PR et al. Circ Res. 2020;126(1):75-90.

Label & Supplement Facts

Average Customer Rating: (34 Reviews) This item can be reviewed only by verified buyers

These reviews have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Great Product

Dianne from Jackson County Michigan

A few years ago my knees were so sore I was having a hard time walking. I was so blessed to find a chiropractor that recommended your SPM product. It has been a life saver for me. Knees get sore from time to time, but much more manageable. Thank you for such a great product and the great service.

3 of 3 people found this review helpful. Do you? yes no Certified buyer

SPM active is amazing

A viewer from Galt, Ca

I first heard about SPM active from my chiropractor. I was being treated for lower back issues. I was at a point where I was going to have back surgery. I began taking SPM active. After 3 weeks of taking SPM active my lower back pain decreased significantly. Im going to continue to take SPM active and I am signed up for automatic shipment. This product is amazing. (Promotional Review)

2 of 2 people found this review helpful. Do you? yes no Certified buyer

Worth the price

A viewer from Limestone, TN

For the longest time I was struggling with pain in my ankles, knees, shoulders... most of my joints. My doctor recommended SPM Active. It greatly reduced the inflammation and pain in my joints, and I could feel a difference within a couple of days of starting this supplement. It is not the cheapest joint supplement, but it works better than anything I have tried. I've now been using this for the past 3 years, and count it as a permanent part of my health regimen. Also, by signing up for the auto-shipment, you get the supplement at a discounted price and it ensures you do not run out. Their subscriptions are very easy to manage, they email several days before they prepare to ship each time allowing you to change the date, pause the subscription, whatever you need. Very happy with this product! (Promotional Review)

1 of 1 people found this review helpful. Do you? yes no Certified buyer

SPM Active

A viewer from Walnut Creek, CA

Product helps with everyday aches and pains (Promotional Review)

1 of 1 people found this review helpful. Do you? yes no Certified buyer

Best Omega

A viewer from Illinois

This is the best Omega I have taken. It has ver little stomach upset. Directed by my Dr. we did worked our way up to 4 pills a day then back down to one or two as needed. I can tell such a different in my joints and legs. This is a great product! (Promotional Review)

1 of 1 people found this review helpful. Do you? yes no Certified buyer

1-5 of34

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SPM Active® for Body and Joint Support*

Supplement Facts

Supplement Facts

To address the immune response, we first need to define it.

In a perfect world, the immune response should resolve itself.

But SPM production may be lacking.

That’s where SPM Active can help.

Why choose SPM Active?

We were the first.

We expand the boundaries of nutritional science

The role of SPMs in the body

Resources

References

Label & Supplement Facts

Great Product

SPM active is amazing

Worth the price

SPM Active

Best Omega