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Serenagen®

Serenagen is a classic herbal stress management formula used in traditional Chinese medicine to nourish and quiet the heart.*

Stress, Mental Health
Sleep
Brain & Cognitive Health

New to Metagenics? Get 15% off your first order + free shipping! Auto-applied at checkout.

Select Container Size

Why you'll love Serenagen®

Serenagen® is a plant-based herbal supplement designed to help your body better handle everyday stress and support a calm, balanced mood.* This adaptogenic blend features traditional herbs like Rehmannia, Schisandra, Jujube, and Asian Ginseng to promote relaxation without drowsiness.* Taken daily, Serenagen® helps you stay centered, resilient, and composed—naturally.*


Triple tested. Practitioner trusted.

For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:

  • Produced in GMP certified facilities to meet the highest quality standards.
  • Science-backed: We perform +200K quality tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
  • Triple tested: All our products are verified for identity, purity, strength, and stability at three levels of production: ingredient, formula, and encapsulation.
  • Metagenics is the #1 Doctor-Recommended Professional Supplement Brand trusted by 50,000 healthcare practitioners.
  • Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly, and with purpose.
  • Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee.

Allergen Information

Non-GMO | Gluten-Free | Vegetarian

IngredientsAmount Per Serving% Daily Value
Serving Size2 Tablets
Servings Per Container30
Total Carbohydrate<1 g<1%**
Dietary Fiber<1 g2%**
A 4:1 Proprietary Herbal Extract Blend of: Rehmannia Root (Rehmannia glutinosa), Schisandra Fruit (Schisandra chinensis), Jujube Fruit (Ziziphus spinosa), Dong Quai Root (Angelica sinensis), Chinese Asparagus Root (Asparagus cochinchinensis), Ophiopogon Root (Ophiopogon japonicus), Scrophularia Root (Scrophularia ningpoensis), Asian Ginseng Root (Panax ginseng), Chinese Salvia Root (Salvia miltiorrhiza), Poria Fungus (Wolfiporia cocos), Polygala Root (Polygala tenuifolia), Platycodon Root (Platycodon grandiflorum)1 g***

Other Ingredients: Microcrystalline cellulose, croscarmellose sodium, cellulose, stearic acid (vegetable), silica, magnesium stearate (vegetable), and coating (hypromellose, medium-chain triglycerides, and hydroxypropylcellulose).



SKU: SE

Take two tablets daily or as directed by your healthcare practitioner.

Dry Place

  • Do not use if pregnant or nursing.

Frequently bought together

  • Adreset®

    Stress leaving you feeling drained? Support resilience & stamina with Adreset® adaptogen supplements

    4.8
    Adreset®
  • MethylCare®

    Supports vascular system by aiding the methylation process*

    4.8
    MethylCare®
  • NuSera®

    Relief for stressful moments.*

    NuSera®
A panel titled “Did You Know?” showing text about the high percentage of U.S. adults experiencing stress and noting that nutritional and herbal supplements can help with anxiety‑related conditions, with circular images of herbs.
A person sitting calmly and smiling beside text explaining that Serenagen combines time‑tested Traditional Chinese Medicine herbs to help the body adapt to stress, support emotional balance, promote calm non‑sedating focus, and support everyday resilience.
Two tablets shown with a Serenagen bottle in the background next to text instructing to take two tablets daily, with or without food, or as directed by a healthcare practitioner.
A hand holding a Serenagen bottle beside a customer review describing significant improvements in stress and thyroid‑related symptoms, shown with five stars and the name Maria V. as a verified customer.
Stress, Mental Health
Sleep
Brain & Cognitive Health

New to Metagenics? Get 15% off your first order + free shipping! Auto-applied at checkout.

Select Container Size

Why you'll love Serenagen®

Serenagen® is a plant-based herbal supplement designed to help your body better handle everyday stress and support a calm, balanced mood.* This adaptogenic blend features traditional herbs like Rehmannia, Schisandra, Jujube, and Asian Ginseng to promote relaxation without drowsiness.* Taken daily, Serenagen® helps you stay centered, resilient, and composed—naturally.*


Triple tested. Practitioner trusted.

For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:

  • Produced in GMP certified facilities to meet the highest quality standards.
  • Science-backed: We perform +200K quality tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
  • Triple tested: All our products are verified for identity, purity, strength, and stability at three levels of production: ingredient, formula, and encapsulation.
  • Metagenics is the #1 Doctor-Recommended Professional Supplement Brand trusted by 50,000 healthcare practitioners.
  • Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly, and with purpose.
  • Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee.

Allergen Information

Non-GMO | Gluten-Free | Vegetarian

IngredientsAmount Per Serving% Daily Value
Serving Size2 Tablets
Servings Per Container30
Total Carbohydrate<1 g<1%**
Dietary Fiber<1 g2%**
A 4:1 Proprietary Herbal Extract Blend of: Rehmannia Root (Rehmannia glutinosa), Schisandra Fruit (Schisandra chinensis), Jujube Fruit (Ziziphus spinosa), Dong Quai Root (Angelica sinensis), Chinese Asparagus Root (Asparagus cochinchinensis), Ophiopogon Root (Ophiopogon japonicus), Scrophularia Root (Scrophularia ningpoensis), Asian Ginseng Root (Panax ginseng), Chinese Salvia Root (Salvia miltiorrhiza), Poria Fungus (Wolfiporia cocos), Polygala Root (Polygala tenuifolia), Platycodon Root (Platycodon grandiflorum)1 g***

Other Ingredients: Microcrystalline cellulose, croscarmellose sodium, cellulose, stearic acid (vegetable), silica, magnesium stearate (vegetable), and coating (hypromellose, medium-chain triglycerides, and hydroxypropylcellulose).



SKU: SE

Take two tablets daily or as directed by your healthcare practitioner.

Dry Place

  • Do not use if pregnant or nursing.

Frequently bought together

  • Adreset®

    Stress leaving you feeling drained? Support resilience & stamina with Adreset® adaptogen supplements

    4.8
    Adreset®
  • MethylCare®

    Supports vascular system by aiding the methylation process*

    4.8
    MethylCare®
  • NuSera®

    Relief for stressful moments.*

    NuSera®

Frequently Asked Questions

Serenagen® is a plant-based supplement designed to help your body better manage everyday stress and support a calm, balanced mood. It combines adaptogenic herbs traditionally used to promote relaxation and emotional resilience without causing drowsiness. This makes it a great option for those dealing with occasional stress, tension, or feeling overwhelmed in daily life. Support your stress response naturally—try Serenagen® today and feel more centered day after day.

Serenagen® features adaptogens—herbs that help your body adapt to physical and mental stress by supporting balance in your stress-response systems. Ingredients like Schisandra and Asian Ginseng have traditionally been used to help reduce fatigue and promote calm focus during stressful situations.   Help your body stay calm under pressure—start your Serenagen® routine today.

Yes, Serenagen® is a natural, plant-based stress support supplement inspired by traditional Chinese medicine. It uses a blend of herbal extracts rather than synthetic ingredients to promote relaxation and emotional well-being, making it ideal for those seeking a more holistic approach to stress management. Choose a natural approach to stress relief—try Serenagen® risk-free today.

No—Serenagen® is designed to promote relaxation without causing drowsiness. Unlike some stress or sleep supplements, it helps you stay calm, focused, and composed throughout the day so you can function at your best. Stay calm and alert at the same time—experience the difference with Serenagen®.

While results can vary, many users report feeling more balanced and less reactive to stress with consistent daily use over time. Because Serenagen® works by supporting your body’s natural stress response, it’s best taken regularly for ongoing benefits rather than immediate effects.   Build lasting stress resilience—take Serenagen® daily and track your progress.

Serenagen® stands out for its synergistic blend of 12 traditional herbs formulated to support emotional balance and stress resilience in a gentle, non-sedating way. Its adaptogenic formula helps your body respond to stress more effectively, rather than simply masking symptoms. Upgrade your stress support routine—discover Serenagen® today and feel more in control.

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